DNMT1 and nonpapillary renal cell carcinoma: In addition, the DNA methyltransferase DNMT1 (P < 0.001), DNMT2 (P < 0.05), DNMT3 (P < 0.001), DNMT4 (P < 0.001) were also significantly associated with the CDCA7 expression level in ccRCC (Fig. 6c).