On the basis of the normalized enrichment score (NES) and FDR q-val (FDR < 0.01), the most significantly enriched biological pathways were exhibited (Table 2; Fig. 4), which were apoptosis pathway, cell cycle pathway, JAK-STAT pathway, NOD like receptor pathway, P53 pathway, T cell receptor pathway and toll like receptor pathway (Fig. 4a–h), to uncover the potential regulatory mechanism of CDCA7 in ccRCC. This evidence concerns the gene SOAT1 and nonpapillary renal cell carcinoma.