On the basis of the normalized enrichment score (NES) and FDR q-val (FDR < 0.01), the most significantly enriched biological pathways were exhibited (Table 2; Fig. 4), which were apoptosis pathway, cell cycle pathway, JAK-STAT pathway, NOD like receptor pathway, P53 pathway, T cell receptor pathway and toll like receptor pathway (Fig. 4a–h), to uncover the potential regulatory mechanism of CDCA7 in ccRCC. Here, TP53 is linked to nonpapillary renal cell carcinoma.