NGF and osteonecrosis: For the safety evaluation, injected joints were evaluated in addition to TEAEs by target joint examination and structural changes because NSAIDs were reported to be deleterious for cartilage [20], and the progression of joint destruction, joint space narrowing, or osteonecrosis was reported in OA patients treated with anti-nerve growth factor antibody or continuous treatment of IA corticosteroids [21, 22].