Among those prognosis-specific immune related genes, 14(e.g., CCT6A, EFNB2, FKBP3, FERMT2, SMAD9, GATA2, PFKP, PKP2, PTPRH, CCL20, SLC7A5, DDIT4, LY6K, ITIH4) have been demonstrated to be participate in the the pathogenesis of cancer or reported to be significant predictors of survival [39–46]. This evidence concerns the gene EFNB2 and cancer.