SMAD9 and cancer: Among those prognosis-specific immune related genes, 14(e.g., CCT6A, EFNB2, FKBP3, FERMT2, SMAD9, GATA2, PFKP, PKP2, PTPRH, CCL20, SLC7A5, DDIT4, LY6K, ITIH4) have been demonstrated to be participate in the the pathogenesis of cancer or reported to be significant predictors of survival [39–46].