Among those prognosis-specific immune related genes, 14(e.g., CCT6A, EFNB2, FKBP3, FERMT2, SMAD9, GATA2, PFKP, PKP2, PTPRH, CCL20, SLC7A5, DDIT4, LY6K, ITIH4) have been demonstrated to be participate in the the pathogenesis of cancer or reported to be significant predictors of survival [39–46]. The gene discussed is PKP2; the disease is cancer.