In this study, the analysis of gene expression profiles of adenomas and adenocarcinomas by microarrays and signaling pathways analysis revealed many pathways and cellular processes associated with extracellular matrix remodeling, angiogenesis and epithelial-mesenchymal transition, as well as the IGF (Insulin-like growth factor) signaling pathway, which is known to be directly linked to colorectal cancer (Metacore from Clarivate Analytics) (Table S3, Additional File 5). The gene discussed is IGF1; the disease is adenoma.