ETV4 and Familial prostate cancer: The reduction in proliferation demonstrated by Hollenhorst et al (2011) [51] in prostate cancer cell lines after ETV4 inhibition was found in combination with a decreased MYC gene expression, due to the direct regulation of MYC by ETV4. Our findings are in agreement with the reduced proliferation after ETV4 inhibition however, we identified an increase in MYC gene expression in adenocarcinomas as compared to adenomas.