EGFR and non-small cell lung carcinoma: The efficacy of afatinib in treating patients with EGFR mutation-positive NSCLC was established in the global, phase III LUX-Lung 3 study [12], the phase III LUX-Lung 6 study in Asian patients [13], and the global, phase IIb LUX-Lung 7 study [14, 15].