In the HF diet-induced obese mice, we showed that adipocyte-specific deletion of ILK caused smaller epididymal fat pads, decreased percent fat mass, and partially ameliorated insulin resistance in adipose tissue by increasing glucose uptake in BAT and enhancing the inhibitory action of insulin on lipolysis as measured by plasma NEFA levels as a surrogate marker. The gene discussed is INS; the disease is hydrops fetalis.