Consistent with the observation in zebrafish, mutations in the human gene encoding Eag1 (KCNH1) were recently reported in individuals with two congenital neurodevelopmental disorders: Temple–Baraitser syndrome (TMBTS) (14) and Zimmermann–Laband syndrome (ZLS) (15, 16). The gene discussed is KCNH1; the disease is Temple-Baraitser syndrome.