CTNNB1 and cancer: To determine whether there is an interaction between PANX1 and β-catenin in melanoma cells, we first analyzed a panel of melanoma biopsies from the Cancer Genome Atlas (TCGA) and found a modest, yet significant, correlation between PANX1 and β-catenin mRNA (CTNNB1) in 471 patients with malignant melanoma (Fig. 1A, left panel).