WRN and cancer: A number of experimental and computational studies have implicated RECQ helicases – primarily BLM and WRN - as potential targets for cancer therapy, due to the synthetic lethality of their silencing or downregulation with genetic defects inherent in a range of different cancers (Chan et al., 2019; Lieb et al., 2019; Aggarwal and Brosh, 2009; Behan et al., 2019; Datta et al., 2021; Kategaya et al., 2019; Pearl et al., 2015; Wang et al., 2018).