Thus, the down-regulation of BAP31 expression during viral infection in turn promotes DnaJB11 expression and tubule assembly, finally facilitating viral transmission by S. furcifera. Taken together, we show that a fine virus-mediated regulation of protein quality control has evolved for activation of DnaJB11 for ensuring the proper assembly of virus-induced tubules to support viral propagation and transmission by insect vectors (Fig 8). Here, DNAJB11 is linked to viral infectious disease.