CD8A and neoplasm: Correlations of many of these markers with effective immune responses were demonstrated in mice challenged with tumor cells that were exposed in vitro to NTP; both the innate and adaptive immune responses were stimulated as demonstrated by increased infiltration of different immune cell subsets into tumors, cancer cell-specific systemic CD8+ T cell responses, decreased tumor size and burden, and increased survival of mice with metastatic cancer [15–20].