Among the different infections, median CRP levels of both bacteremia cases (107, IQR 44–142, n = 65) and all confirmed bacterial infections without malaria co-infection (97 mg/L, IQR 47–134; n = 109) were significantly higher than those obtained from clinical malaria cases (51 mg/L, IQR 22–100, n = 180; p < .0001 in both analyses). Here, CRP is linked to bacterial infectious disease.