CD4 and psychotic disorder: Using a random effects meta-analysis to combine the results across the seven cohorts, which were adjusted for age, sex, and DNAm smoking score, we found that psychosis cases had elevated estimated proportions of granulocytes (mean difference = 0.0431; p=5.09×10−4) and monocytes (mean difference = 0.00320; p=1.15×10−4), and significantly lower proportions of CD4+ T-cells (mean difference = −0.0177; p=0.00144), CD8+ T-cells (mean difference = −0.0144; p=0.00159), and natural killer cells (mean difference = −0.0113; p=0.00322) (Table 2 and Figure 2).