PYCARD and Parkinson disease: Specifically, recent studies have shown the ASC and caspase‐1 released from microglia trigger the neuronal accumulation of α‐syn aggregates (Wang et al, 2016; Gordon et al, 2018), and thus, inhibition of the glial inflammasome pathway abolished α‐synucleinopathy in a PD animal model (Gordon et al, 2018).