In accord with the in vitro findings shown in Figs 1J–M and 2D–E, mRNA expression of the pro‐inflammatory cytokines (Il1b, Tnfa) and key inflammasome components (Nlrp3, Asc, Casp1) was significantly lowered in the SNs of MPTP‐ and SNCA‐PD model mice by administering the SGK1 inhibitor (Fig 9F and G). This evidence concerns the gene PYCARD and Parkinson disease.