In addition to preventing SNCA pathology (% p129‐SNCA+ cells), mDA neuron degeneration in the SN (Fig 8I–M) and loss of TH+ and DA transporter (DAT)+ fiber intensities in the striatum (Fig 8N and O), intra‐SN injection of sh‐Sgk1‐AAV9 ameliorated behavioral deficits in SNCA model PD mice (Fig 8F–H). Here, SGK1 is linked to Parkinson disease.