SGK1 and early-onset autosomal dominant Alzheimer disease: SGK1 expression is widely detected in the brain, and it is increased in pathologic conditions such as Rett syndrome (Nuber et al, 2005), Alzheimer disease (Chun et al, 2004; Lang et al, 2010; Zhang et al, 2018), multiple sclerosis (Wang et al, 2017), amyotrophic lateral sclerosis (Schoenebeck et al, 2005), and neuropathic pain (Geranton et al, 2007; Peng et al, 2013).