The key NLRP3‐inflammasome component ASC was barely detected in un‐lesioned mice (data not shown and (Gordon et al, 2018)), whereas ASC immunoreactivity was abundantly detected and localized in hypertrophic Iba1+ microglia in the SN area of control SNCA‐PD mice (Fig 9H). This evidence concerns the gene PYCARD and Parkinson disease.