NGF and Parkinson disease: The main findings of this study are: (1) iron accumulation induces cytotoxicity in neural-like cells in a dose- and time- dependent manner; (2) PC12-NGF cell is one of the most sensitive cells to the toxic effect of iron; (3) both apoptosis and ferroptosis pathway are activated in PC12-NGF cells under FAC administration; (4) activated ferroptosis may be one of the mechanisms of MPP+ induced PD in vitro model; (5) iron chelator DFO could inhibit ferroptosis and have a protective role in PD cell model.