Increasing numbers of first-degree and second-degree family members with breast cancer were associated with higher odds of having a BRCA1 (OR, 1.93; 95% CI, 1.68-2.21; P < .001) and a BRCA2 variant (OR, 1.52; 95% CI, 1.26-1.85; P < .001). The gene discussed is BRCA1; the disease is breast cancer.