In general, PTH attenuate osteoarthritis by maintaining microarchitecture of the subchondral bone and protection of articular cartilage (Sampson et al., 2011; Orth et al., 2013; Bellido et al., 2011; Yan et al., 2014; Chang et al., 2009; Lugo et al., 2012; Morita et al., 2018; Dai et al., 2016; Chen et al., 2018; Petersson et al., 2006). The gene discussed is PTH; the disease is osteoarthritis.