PTH1R and osteoarthritis: In Pth1r−/− mice, iPTH was ineffective at maintaining the microarchitecture of tibial subchondral bone after DMM surgery, including Tb.Pf, SMI, Po.V(tot), and SBP.Th (Figure 7C,D), but the protective effect of iPTH was re-demonstrated in Pth1r+/+ mice after DMM surgery, suggesting that iPTH maintains the subchondral microarchitecture in osteoarthritis via its effect on MSCs.