Aberrant subchondral bone remodeling is a critical factor in pathological changes of osteoarthritis (Zhen and Cao, 2014; Zhen et al., 2013), and sensory innervation induced by netrin-1 from aberrant subchondral bone remodeling is responsible for osteoarthritis pain (Zhu et al., 2019). Here, NTN1 is linked to osteoarthritis.