Meanwhile, GAS5 inhibition decreased the contents of cTnI and CK-MB in mouse serum (all P<0.01) (Figure 2D), as well as the levels of TNF-α, IL-6 and IL-1β (all P<0.01) (Figure 2E), and the NO content in myocardial tissues (P<0.01) (Figure 2F), while overexpression of GAS5 exacerbated the inflammation and myocardial depression/injury in mice with sepsis (all P<0.05) (Figure 2D-F). This evidence concerns the gene IL1B and Sepsis.