Our results showed that the mRNA and protein levels of NLRP3, ASC and Caspase-1 in the lungs of OVA-induced asthmatic mice were notably down-regulated after ACG treatment, suggesting that ACG might inhibit the inflammatory response in OVA-induced asthma by suppressing the NLRP3 inflammasome. This evidence concerns the gene CASP1 and asthma.