MUC2 and colitis: Importantly, Winnie mice respond to anti-inflammatory drugs that are used clinically to treat patients with UC, including glucocorticoids12 and thiopurines.13 In both cases, suppression of Winnie colitis is accompanied by reduced ER stress and UPR activation, less Muc2 misfolding, restoration of mature mucin production, and amelioration of goblet cell depletion.