It is likely that p62 protein, although represented as an important receptor for mitophagy in Parkinson's disease, is not necessary weighing equal when it transfer into pathologyduring ageing, in fact researches have gradually uncovered NIX/BNIP3L, BNIP3 and FUNDC1 as mitophagy receptors in mammalian system,28, 29, 30, 31, 32, 33, 34 which may explain insufficient interaction between p62 and autophagy activity regulation by acupoint catgut embedding here. The gene discussed is BNIP3; the disease is Parkinson disease.