Among the dysregulated genes in astrocytes, we detected upregulation of Apoe, the key risk variant gene for Alzheimer’s disease, Rora, a nuclear hormone receptor linked to intellectual disability, epilepsy and autism (Guissart et al, 2018) and downregulation of Auts2, a transcriptional regulator linked to several neurodevelopmental disorders (Oksenberg & Ahituv, 2013). Here, AUTS2 is linked to early-onset autosomal dominant Alzheimer disease.