Dysregulation of the activity or expression of HSP27 can result in debilitating diseases, including cancers (Ciocca & Calderwood, 2005; Straume et al,2012), neurodegenerative diseases (Outeiro et al,2006), and neuropathies (Evgrafov et al,2004). The gene discussed is HSPB1; the disease is neuropathy.