While the majority of CMT‐associated mutations in HSPB1 reside in the structured ACD (Adriaenssens et al,2017; Weeks et al,2018), mutations within the disordered NTD and CTR also cause CMT disease (Chalova et al,2014; Muranova et al,2015). Here, HSPB1 is linked to Charcot-Marie-Tooth disease.