SLC6A3 and schizophrenia: Furthermore, using the dopamine transporter (DAT) knockout model of schizophrenia in mice (Giros et al. 1996; Hill and Tasker 2012) characterised by hyperdopaminergia primarily within the striatum and nucleus accumbens (Kasahara et al. 2013), it has been shown that DAT knockout mice present with reduced levels of the endocannabinoid, anandamide within the striatum (Tzavara et al. 2006).