To confirm that the anti-human P2Y12R antibody recognized microglia, double-immunostaining with anti-human P2Y12R and Iba1 antibodies was performed for the hippocampal sections of a healthy control and a patient with senile dementia of NFT type (SD-NFT), a subset of dementia characterized by numerous NFTs in the hippocampal region and absence of amyloid plaques throughout the brain. Here, P2RY12 is linked to dementia.