Taken together with previous findings on accumulations of astrocytes and TSPO-positive microglia in the AD brain (Maeda et al., 2011; Ji et al., 2015; Leyns and Holtzman, 2017), the current data provide evidence for the glial activation induced by AD pathologies accompanying notable P2Y12R declines. The gene discussed is TSPO; the disease is Alzheimer disease.