Furthermore, it has been suggested that E2 exerts the following adaptive effects on the renin–angiotensin system (RAS) pathway to prevent hypertension: (1) E2 enhances signaling of angiotensin II (Ang II) via angiotensin II receptor type 2 (AT2R) to facilitate vasodilation (2, 46) E2 upregulates angiotensin-converting enzymes (ACE) 2 expression to enhance the conversion of Ang II to Ang-(1–4, 29–31) for signaling via Mas receptor (MasR) to facilitate vasodilation (47). This evidence concerns the gene AGT and hypertensive disorder.