PKC is a serine/threonine kinase involved in signal transduction, is the effector in the G protein coupled receptor system, in recent years, many studies have shown that PKC played a very important role in many cardiovascular system diseases such as atherosclerosis and vascular calcification, hypertension, myocardial ischemia-reperfusion injury, the occurrence of heart failure and arrhythmia development (Bynagari-Settipalli et al., 2010). Here, PRRT2 is linked to heart failure.