INS and obesity due to melanocortin 4 receptor deficiency: Similarly, in boys with obesity, there was a higher expression of insulin (p <0.0001), leptin (p <0.0001), c-peptide (p < 0.0001), amylin (p = 0.0013), glucagon (p = 0.04), GLP-1 (p < 0.0001), and ghrelin (p = 0.07), compared to the eutrophic group.