HLA-DRB1 alleles such as HLA-DRB1*0405 (OR: 3.493, 95% CI: 2.103–5.801, pc = 0.0003), HLA-DRB1*1502 (OR = 1.586, 95% CI: 1.132–2.221, pc = 0.014), and HLA-DRB1*1602 (OR = 2.061, 95% CI: 1.1579–3.668, p < 0.05, pc = 0.024) were likely associated with the increased risk of developing SLE (with and without LN), while HLA-DRB1*1201 (OR: 0.069, 95% CI: 0.017–0.281, p = 0.0002) and HLA-DRB1*1202 (OR: 0.498, 95% CI: 0.299–0.831, p = 0.007) alleles were probably associated with a lower risk of developing SLE (with and without LN). Here, HLA-DRB1 is linked to lobular neoplasia.