Significantly increased in SLE carriers with HLA-DRB1*04 allele - IFN-γ and GM-CSF (Th1 subset) - IL-17F and IL-21 (Th17 subset) -IL-18 and VEGF (other cytokines) Significantly reduced in SLE carriers with HLA-DRB1*04 allele - IL-5 (Th2 subset - LPO and CAT (Free radicals). This evidence concerns the gene IL21 and systemic lupus erythematosus.