HLA-DRB1*15, HLA-DRB1*04, and HLA-DRβ1*16 were the most frequent and common alleles among all the HLA-DRB1 alleles identified in SLE patients with and without LN involvement, suggesting a significant role for these alleles in SLE disease. Here, HLA-DRB1 is linked to systemic lupus erythematosus.