Moreover, DHX15 not only dysregulates genes downstream of the NF-kB signaling pathway, an important mechanism of its antitumour function, but also downregulates genes involved in splicing and ribosomal biogenesis in glioma, indicating that DHX15 regulates glioma at the post-transcriptional level (18). The gene discussed is NFKB1; the disease is central nervous system cancer.