VSIG4 and lupus nephritis: A novel CRIg/FH fusion protein, combining the extracellular domain of CRIg and the functional domain of factor H, was designed to inhibit both the classical and alternative complement pathway and displayed similar effects in ischemia-reperfusion injury and lupus nephritis (Qiao et al., 2018; Hu et al., 2019; Shi et al., 2019).