IGF-I, IGF-II, Survivin, and sTNF-R1 are all antiapoptotic factors and participate in the occurrence and progression of RCC (Rosendahl et al., 2008; Sánchez-Lázaro et al., 2012; Carew et al., 2015; Solarek et al., 2019). The gene discussed is IGF1; the disease is renal cell carcinoma.