The results showed that pretreatment of exosomes derived from RPS3-overexpressing SGC7901R cells following incubation with cisplatin showed the highest levels of cisplatin concentration in the xenograft tumor compared with cisplatin alone, while the pretreatment of exosomes derived from RPS3-silencing SGC7901R cells following incubation with cisplatin did the opposite effect (Figure 6D). This evidence concerns the gene RPS3 and neoplasm.