The IHC images demonstrated that pretreatment of exosomes derived from RPS3-overexpressing SGC7901R cells following incubation with DDP showed the highest expression levels of p-PI3K and p-AKT and the lowest expression levels of PP1 and PP2A in the xenograft tumor compared with DDP alone, while the pretreatment of exosomes derived from RPS3-silencing SGC7901R cells following incubation with DDP did the opposite effect (Figure 6F). Here, AKT1 is linked to neoplasm.