Additionally, glioma cells implanted into irf8−/− transgenic zebrafish that lack microglia and wild-type zebrafish treated with CSF-1 inhibitor (a pharmacological means of decreasing microglia) have demonstrated a unique role for zebrafish microglia in facilitating human glioma cell growth (Hamilton et al., 2016). The gene discussed is CSF1; the disease is central nervous system cancer.