The Tg(fli:eGFP) zebrafish line with GFP-labeled vasculature contributes largely to studies on the mechanism of tumor neovascularization and evaluations of the efficacy of antiangiogenic agents (Tran et al., 2007; Fior et al., 2017; Gaudenzi et al., 2017; Britto et al., 2018, 2019; Cirello et al., 2018; Garcia-Caballero et al., 2018). This evidence concerns the gene FLII and neoplasm.