Comprehensive analysis of gene expression in normal brains and the brains of patients with psychiatric disorders would delineate the significance of redox-sensitive TRP channels in these disorders, where notably, TRPM2 expression is enhanced in hippocampal tissue samples from patients with major depressive disorder (Ko et al., 2019), and, furthermore, TRPA1 is upregulated in astrocytes of the hippocampus in the mouse model of Alzheimer’s disease, in which oxidative stress is deeply involved (Lee et al., 2016). This evidence concerns the gene TRPM2 and early-onset autosomal dominant Alzheimer disease.