TRPM2 and major depressive disorder: In a mouse model of depression via chronic unpredictable stress, disruption of Trpm2 produced antidepressant-like behaviors accompanied by reduced ROS, suppressed ROS-induced calpain activation, and enhanced phosphorylation of two Cdk5 targets, synapsin 1 and histone deacetylase 5, which are linked to synaptic function and gene expression, respectively (Ko et al., 2019).