In rat cultured astrocytes, tert-butyl hydroperoxide-induced oxidative stress upregulates TRPM2 mRNA within 1 h – the transcripts were peaked at 4 h and were still apparent at 24 h post-stress (Bond and Greenfield, 2007), suggesting that glial TRPM2 expression is enhanced upon oxidative stress in disease conditions, including psychiatric disorders, and mediates the pathophysiology of disease. The gene discussed is TRPM2; the disease is psychiatric disorder.