Interestingly, vascular endothelial cell-specific Trpa1 KO exacerbates cerebral infarcts following permanent middle cerebral artery occlusion in mice (Pires and Earley, 2018), suggesting that TRPA1 in cerebral artery endothelial cells is activated by oxidative stress under ischemia and protects from cerebral ischemia through the secretion of vasodilators, including NO. This evidence concerns the gene TRPA1 and brain ischemia.