The absence of tumor neoantigen expression and presentation leads to a lack of recognition by T-cells and results in the inability of tumors to respond to PD-1/PD-L1 inhibitor therapy (Bai J. et al., 2017), moreover, other alterations such as apoptosis suppression or DNA repair promoted are also associated with treatment resistance (Mansoori et al., 2017). Here, CD274 is linked to neoplasm.