AQP1 and malignant colon neoplasm: Therefore, AQP1 has been suggested as a possible therapeutic target for several tumors including tumors of the central nervous system as well as other solid tumors like melanoma or colon cancer (Deb et al., 2012; Wei and Dong, 2015; Dorward et al., 2016; Jagirdar et al., 2016; Pei et al., 2016; Wang et al., 2017; Simone et al., 2018; Yang et al., 2018).