HIF-1α and several other hypoxia related genes such as pyruvate dehydrogenase 1 (PDK1), PGK1, carbonic anhydrase IX (CAIX) and prolyl hydroxylase 3 (PHD3) have been linked to high risk neuroblastoma (Qing et al., 2010; Dungwa et al., 2012; Ameis et al., 2013, 2016a, b). This evidence concerns the gene PDK1 and neuroblastoma.