AQP1 and HIF-1α have also been associated with invasiveness and migration in neuroblastoma and other cancers as well as with resistance to chemotherapy (Hussein et al., 2006; Smith et al., 2010; Chen et al., 2015; Sun et al., 2017; Guan et al., 2018; Sato et al., 2018). This evidence concerns the gene HIF1A and cancer.