For example, the two receptors of TNF, TNF receptor-1 (TNFR1) and TNF receptor-2 (TNFR2), regulate the interaction of the various types of immune cells and also the interplay of the latter with practically any type of non-hematopoietic cells; CD40 stimulates antigen-presenting cells; CD27, OX40, 41BB, and RANK costimulate T cells; BCMA, TACI, and BaffR regulate B-cell maturation; CD95 and the two death receptors of TRAIL contribute to tumor surveillance; Fn14 promotes tissue repair; and EDAR drives the development of skin appendages (Aggarwal et al., 2012). Here, FAS is linked to neoplasm.