Recently, it has been shown that wtp53 improves metabolic adaptation and favors tumor progression by PUMA regulation, a proapoptotic protein overexpressed in hepatocellular carcinoma, and by increasing mitochondrial activity through oxidative phosphorylation (Bensaad et al., 2006; Puzio-Kuter, 2011). This evidence concerns the gene BBC3 and hepatocellular carcinoma.