Under co-culture conditions of colon cancer cell lines (expressing endogenous mutp53) with M0 and M2 macrophages, it has been observed that the macrophages showed an increase in the release of IL-10, MM-9 (metallopeptidase matrix 9), VNN-1 (non-inflammatory vascular molecule 1), and TGF-βI, due to the action of miR-1246-containing exosomes secreted by tumor cells. This evidence concerns the gene VNN1 and colonic neoplasm.