In a mouse zymosan-induced peritonitis model, intraperitoneal injection of 1.5 × 106 BM-derived MSC spheroids for a 6-h time-frame resulted in decreased protein content and volume of the lavage fluid, neutrophil activity, and decreased levels of TNFα, IL-1β, CXCL2/MIP-2, and PGE2. Here, CXCL2 is linked to peritonitis.