Beside positions K31, Y41, and K353 reported in several studies to have been playing a major role for SARS-CoV-2 spike binding to ACE2, our multisequence alignment suggested that species carrying an N90 are more likely to be susceptible to SARS-CoV-2 infection (it includes H. sapiens, M. mulatta, F. catus, R. sinicus, M. javanica, and P. sinensis) while others should be less susceptible to infection, except if the virus adapts to a second receptor for cellular binding and entry. The gene discussed is ACE2; the disease is infection.