Low/normal neutrophil intrinsic granulocyte macrophage colony-stimulating factor (GM-CSF) signaling was found to be associated with colony-stimulating factor 2 receptor A subunit (CSF2RA) missense mutations, where neutrophils from IBD patients exhibited alterations in gene expression regulating cytokine production, wound healing, cell survival, and proliferation (31). The gene discussed is CSF2; the disease is inflammatory bowel disease.