Some established oncogenes are also direct targets of miR-655 in other types of cancers, such as Prrx1 in breast cancer (35), ZEB1 and TGFBR2 in ESCC (36), ADAM10 in hepatocellular carcinoma (31), and PAX6 in retinoblastoma (30). Here, TGFBR2 is linked to esophageal squamous cell carcinoma.