Some established oncogenes are also direct targets of miR-655 in other types of cancers, such as Prrx1 in breast cancer (35), ZEB1 and TGFBR2 in ESCC (36), ADAM10 in hepatocellular carcinoma (31), and PAX6 in retinoblastoma (30). This evidence concerns the gene ADAM10 and retinoblastoma.