ADARB1 and amyotrophic lateral sclerosis: reported a circular RNA edited by ADAR2 named circGRIA2 (hsa_circ_0125620) in mouse spinal motor neurons and human SH-SY5Y cells, and circGRIA2 editing level alteration is a potential marker for early serum diagnosis of amyotrophic lateral sclerosis (ALS) since it can be secreted out of the cell (134).