Besides, more MDM2 inhibitors, such as RITA (134), PRIMA1 (135) HLI373 (148), HLI98 (149), MEL23 and MEL24 (150), and RO8994 (136) have been discovered to target MDM2 directly, thereby enhancing p53 activity and exhibiting anti-cancer ability. This evidence concerns the gene TP53 and cancer.