The development of hereditary breast cancer (BC) results in most cases, from highly penetrant pathogenic variants in several genes, of which the most frequently studied are BRCA1 and BRCA2. Pathogenic variants present in these genes predispose to hereditary breast and ovarian cancer (HBOC) syndrome, with related cancers often described as being more aggressive compared to sporadic cancers. This evidence concerns the gene BRCA2 and breast cancer.