AKT1 and familial pancreatic carcinoma: After the pancreatic cancer data from TCGA was clustered on the basis of the PAR1 expression level, the differentially expressed genes between the high- and low-expression groups were analyzed. The Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) enrichment analysis results showed that PAR1 affected the ECM-receptor interaction, the calcium signaling pathway, the PI3K/AKT signaling pathway, and focal adhesion in pancreatic cancer cells (Figure 4D).