The expression level of PAR1 and FAK (P<0.05, R = 0.29), AKT (P<0.05, R = 0.36), and VIM (P<0.05, R = 0.41) were positively correlated (Figure 3C). Thus, PAR1 may regulate the FAK/PI3K/AKT signaling pathway and result in the poor prognosis of patients with pancreatic cancer. This evidence concerns the gene AKT1 and familial pancreatic carcinoma.