For example, a six-gene signature (SQSTM1, AHSA1, VNN2, SMG5, SRXN1, and GLS) and an eight-gene signature (DCAF13, FAM163A, GPR18, LRP10, PVRIG, S100A9, SGCB, and TNNI3K) to predict OS for HCC patients have been reported (38, 39). The gene discussed is GPR18; the disease is hepatocellular carcinoma.