For example, a six-gene signature (SQSTM1, AHSA1, VNN2, SMG5, SRXN1, and GLS) and an eight-gene signature (DCAF13, FAM163A, GPR18, LRP10, PVRIG, S100A9, SGCB, and TNNI3K) to predict OS for HCC patients have been reported (38, 39). This evidence concerns the gene VNN2 and hepatocellular carcinoma.