The signaling pathway of AKT existed in all cells of people and participated in many metabolic processes, such as cell growth, apoptosis, migration, etc. (36, 37). CXCL7 can also play its role through Ras/Raf/mitogen-activated protein kinase (MAPK) signaling pathways associated with tumor angiogenesis (38). This evidence concerns the gene PPBP and neoplasm.