The expression of ENO1 at different pathological stages was significantly different in CESC (F = 2.7, P = 0.0458), LUAD (F = 3.35, P = 0.0189), KICH (F = 4.19, P = 0.00911), PAAD (F = 3.8, P = 0.0113), and LIHC (F = 10.7, P = 1e-06), indicating that ENO1 might play a key role in the progression of these cancers. The gene discussed is ENO1; the disease is cancer.